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                          September 21, 2022

       Debra Frimerman
       General Counsel
       Calyxt, Inc.
       2800 Mount Ridge Road
       Roseville, MN 55113

                                                        Re: Calyxt, Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed September 19,
2022
                                                            File No. 333-267499

       Dear Ms. Frimerman:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Joshua
Gorsky at 202-551-7836 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Peter E. Devlin