August 29, 2019

James Blome
Chief Executive Officer
Calyxt, Inc.
2800 Mount Ridge Road
Roseville, MN 55113

       Re: Calyxt, Inc.
           Registration Statement on Form S-3
           Filed August 13, 2019
           File No. 333-233231

Dear Mr. Blome:

       We have limited our review of your registration statement to those
issues we have
addressed in our comments. In some of our comments, we may ask you to provide
us with
information so we may better understand your disclosure.

       Please respond to this letter by amending your registration statement
and providing the
requested information. If you do not believe our comments apply to your facts
and
circumstances or do not believe an amendment is appropriate, please tell us why
in your
response.

       After reviewing any amendment to your registration statement and the
information you
provide in response to these comments, we may have additional comments.

Registration Statement on Form S-3 filed August 13, 2019

Description of Capital Stock

1.     We note that your forum selection provision identifies the Court of
Chancery of the State
       of Delaware as the exclusive forum for certain litigation, including any
"derivative
       action." Please disclose whether this provision applies to actions
arising under the
       Securities Act or Exchange Act. In that regard, we note that Section 27
of the Exchange
       Act creates exclusive federal jurisdiction over all suits brought to
enforce any duty or
       liability created by the Exchange Act or the rules and regulations
thereunder, and Section
       22 of the Securities Act creates concurrent jurisdiction for federal and
state courts over all
       suits brought to enforce any duty or liability created by the Securities
Act or the rules and
       regulations thereunder. If the provision applies to Securities Act
claims, please also revise
       your prospectus to state that there is uncertainty as to whether a court
would enforce such
 James Blome
Calyxt, Inc.
August 29, 2019
Page 2
         provision and that investors cannot waive compliance with the federal
securities laws and
         the rules and regulations thereunder.
General

2.       To the extent you intend to rely on General Instruction I.B.6 to Form
S-3 for limited
         primary offerings, please disclose on the prospectus cover page the
information called for
         by Instruction 7 to General Instruction I.B.6. Please also confirm to
us your
         understanding of the size limitations for offerings made under General
Instruction I.B.6.
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

       Please contact Laura Nicholson, Special Counsel, at 202-551-3584 or Anne
Parker,
Assistant Director, at 202-551-3611 with any questions.



FirstName LastNameJames Blome                                 Sincerely,
Comapany NameCalyxt, Inc.
                                                              Division of
Corporation Finance
August 29, 2019 Page 2                                        Office of
Transportation and Leisure
FirstName LastName